NIR light/H2O2-triggered nanocomposites for a highly efficient and selective synergistic photodynamic and photothermal therapy against hypoxic tumor cells

In this work, smart near-infrared (NIR) light/H2O2-triggered and O2-evolving nanocomposites were designed and applied for efficient production of (1)O2 by converting a deeply penetrating NIR light into a visible light to excite the photosensitizers and achieve a self-sufficiency of the O2 generation...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2016-06, Vol.52 (51), p.7939-7942
Hauptverfasser:	Zhang, Yu, Shen, Ting-Ting, Kirillov, Alexander M, Liu, Wei-Sheng, Tang, Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Cell Survival - drug effects Dose-Response Relationship, Drug Drug Resistance, Neoplasm - drug effects Humans Hydrogen Peroxide - chemistry Hypoxia - metabolism Hypoxia - pathology Hypoxia - therapy Infrared Rays Male Nanocomposites - chemistry Photochemical Processes Photosensitizing Agents - chemical synthesis Photosensitizing Agents - chemistry Photosensitizing Agents - pharmacology Phototherapy Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Prostatic Neoplasms - therapy Structure-Activity Relationship
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Beschreibung
Zusammenfassung:	In this work, smart near-infrared (NIR) light/H2O2-triggered and O2-evolving nanocomposites were designed and applied for efficient production of (1)O2 by converting a deeply penetrating NIR light into a visible light to excite the photosensitizers and achieve a self-sufficiency of the O2 generation in the photodynamic therapy process to overcome the hypoxia-induced drug resistance.
ISSN:	1364-548X
DOI:	10.1039/c6cc02571d