Lewis acid-promoted [2 + 2] cycloadditions of alkenes with aryl ketenes

Lewis acid-promoted [2 + 2] cycloadditions of alkenes with aryl ketenes

A method for the [2 + 2] cycloaddition of aryl ketenes and alkenes is presented. The process involves the in situ generation of a ketene in the presence of a Lewis acid. The utility of products is demonstrated towards the synthesis of a common scaffold found in several natural product families. A me...

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Veröffentlicht in:Organic & biomolecular chemistry 2016-01, Vol.14 (24), p.5477-548
Hauptverfasser: Rigsbee, E. M, Zhou, C, Rasik, C. M, Spitz, A. Z, Nichols, A. J, Brown, M. K
Format: Artikel
Sprache:eng
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Zusammenfassung:A method for the [2 + 2] cycloaddition of aryl ketenes and alkenes is presented. The process involves the in situ generation of a ketene in the presence of a Lewis acid. The utility of products is demonstrated towards the synthesis of a common scaffold found in several natural product families. A method for the [2 + 2] cycloaddition of aryl ketenes and alkenes is presented.
ISSN:1477-0520
1477-0539
DOI:10.1039/c5ob01837d