Central Corneal Thickness after Cross-linking Using High Definition Optical Coherence Tomography, Ultrasound, Dual Scheimpflug Tomography: A Comparative Study Over One Year

Abstract Purpose To assess central corneal thickness (CCT) and corneal haze in keratoconus eyes following corneal cross-linking (CXL). Design Prospective non-comparative case series. Methods Forty patients (44 eyes) with keratoconus that had serial evaluation for CCT, following CXL, using high definition optical coherence tomography (HD-OCT), ultrasound pachymetry (USP), and dual Scheimpflug tomography. CCT was measured at baseline, then at 2 weeks, 1, 3, 6, and 12 months postoperatively. Results The mean baseline CCT measurements were 470.02 μm, 469.79 μm and 466.66 μm using the HD-OCT, the USP, and dual Scheimpflug tomography respectively (P=0.91). Following CXL, the mean CCT measurements by dual Scheimpflug, at all follow-up periods, were lower compared to mean baseline reading (P