The β-glucosidase assay: a new diagnostic tool for necrotizing enterocolitis. Sensitivity, specificity, and predictive values

We aimed to establish the utility of serum cytosolic β-glycosidase (CBG) assay as a NEC diagnosis tool. CBG activity has been compared in 192 NEC-free (NEC − ) and 13 NEC-affected (NEC + ) neonates, with modified Bell’s stages II/III, born at Reina Sofia University Hospital; additional blood hematol...

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Veröffentlicht in:	European journal of pediatrics 2016-07, Vol.175 (7), p.931-941
Hauptverfasser:	Gómez-Chaparro Moreno, José Luis, Rodríguez Torronteras, Alejandro, Ruiz González, María Dolores, Izquierdo Palomares, Lucía, Bonilla Valverde, Daniel, Ruiz Laguna, Julia, Delgado Rubio, Alfonso, López-Barea, Juan
Format:	Artikel
Sprache:	eng
Schlagworte:	beta-Glucosidase - blood Biomarkers - blood Clinical Enzyme Tests Enterocolitis, Necrotizing - blood Enterocolitis, Necrotizing - diagnosis Female Gestational Age Humans Infant, Newborn Infant, Very Low Birth Weight Intensive Care Units, Neonatal Logistic Models Male Medicine Medicine & Public Health Original Article Pediatrics Predictive Value of Tests Prospective Studies ROC Curve Sensitivity and Specificity
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Zusammenfassung:	We aimed to establish the utility of serum cytosolic β-glycosidase (CBG) assay as a NEC diagnosis tool. CBG activity has been compared in 192 NEC-free (NEC − ) and 13 NEC-affected (NEC + ) neonates, with modified Bell’s stages II/III, born at Reina Sofia University Hospital; additional blood hematology, microbiology, and biochemical parameters have been assayed. NEC + neonates have higher serum CBG activity, 26.4 ± 12.4 mU/mg; 95 % CI (18.8–33.9), than NEC − infants, 11.0 ± 6.6 mU/mg; 95 % CI (10.1–11.9) ( p
ISSN:	0340-6199 1432-1076
DOI:	10.1007/s00431-016-2724-8