Bisphenol A disrupts glucose transport and neurophysiological role of IR/IRS/AKT/GSK3β axis in the brain of male mice
Highlights • The associations of insulin signaling disruption and neurotoxicity were induced by BPA. • Exposure to BPA could interfere glucose uptake in CNS. • Hyperactivation of IR/AKT/GSK3β axis was showed in the brain of BPA treated mice. • Increase of phosphorylated tau and APP was observed in B...
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| Veröffentlicht in: | Environmental toxicology and pharmacology 2016-04, Vol.43, p.7-12 |
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| container_title | Environmental toxicology and pharmacology |
| container_volume | 43 |
| creator | Li, Jing Wang, Yixin Fang, Fangfang Chen, Donglong Gao, Yue Liu, Jingli Gao, Rong Wang, Jun Xiao, Hang |
| description | Highlights • The associations of insulin signaling disruption and neurotoxicity were induced by BPA. • Exposure to BPA could interfere glucose uptake in CNS. • Hyperactivation of IR/AKT/GSK3β axis was showed in the brain of BPA treated mice. • Increase of phosphorylated tau and APP was observed in BPA treated mice. |
| doi_str_mv | 10.1016/j.etap.2015.11.025 |
| format | Article |
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Wang, Yixin ; Fang, Fangfang ; Chen, Donglong ; Gao, Yue ; Liu, Jingli ; Gao, Rong ; Wang, Jun ; Xiao, Hang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c444t-cc25339da1ffa42422fc070da1797cd237d2f890c5c2ef14cd391d52d4d030bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Benzhydryl Compounds - toxicity</topic><topic>BPA</topic><topic>Brain - drug effects</topic><topic>Brain - physiology</topic><topic>Emergency</topic><topic>Endocrine Disruptors - toxicity</topic><topic>Energy Metabolism - drug effects</topic><topic>Glucose - metabolism</topic><topic>Glucose Transport Proteins, Facilitative - metabolism</topic><topic>Glucose transporters</topic><topic>Glycogen Synthase Kinase 3 beta - metabolism</topic><topic>Homeostasis - drug effects</topic><topic>Insulin signaling</topic><topic>Male</topic><topic>Mice</topic><topic>Neurodegenerative diseases</topic><topic>Phenols - toxicity</topic><topic>Proto-Oncogene Proteins c-akt - metabolism</topic><topic>Signal Transduction - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Jing</creatorcontrib><creatorcontrib>Wang, Yixin</creatorcontrib><creatorcontrib>Fang, Fangfang</creatorcontrib><creatorcontrib>Chen, Donglong</creatorcontrib><creatorcontrib>Gao, Yue</creatorcontrib><creatorcontrib>Liu, Jingli</creatorcontrib><creatorcontrib>Gao, Rong</creatorcontrib><creatorcontrib>Wang, Jun</creatorcontrib><creatorcontrib>Xiao, Hang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Environmental toxicology and pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Jing</au><au>Wang, Yixin</au><au>Fang, Fangfang</au><au>Chen, Donglong</au><au>Gao, Yue</au><au>Liu, Jingli</au><au>Gao, Rong</au><au>Wang, Jun</au><au>Xiao, Hang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bisphenol A disrupts glucose transport and neurophysiological role of IR/IRS/AKT/GSK3β axis in the brain of male mice</atitle><jtitle>Environmental toxicology and pharmacology</jtitle><addtitle>Environ Toxicol Pharmacol</addtitle><date>2016-04-01</date><risdate>2016</risdate><volume>43</volume><spage>7</spage><epage>12</epage><pages>7-12</pages><issn>1382-6689</issn><eissn>1872-7077</eissn><abstract>Highlights • The associations of insulin signaling disruption and neurotoxicity were induced by BPA. • Exposure to BPA could interfere glucose uptake in CNS. • Hyperactivation of IR/AKT/GSK3β axis was showed in the brain of BPA treated mice. • Increase of phosphorylated tau and APP was observed in BPA treated mice.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>26923231</pmid><doi>10.1016/j.etap.2015.11.025</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1382-6689 |
| ispartof | Environmental toxicology and pharmacology, 2016-04, Vol.43, p.7-12 |
| issn | 1382-6689 1872-7077 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Benzhydryl Compounds - toxicity BPA Brain - drug effects Brain - physiology Emergency Endocrine Disruptors - toxicity Energy Metabolism - drug effects Glucose - metabolism Glucose Transport Proteins, Facilitative - metabolism Glucose transporters Glycogen Synthase Kinase 3 beta - metabolism Homeostasis - drug effects Insulin signaling Male Mice Neurodegenerative diseases Phenols - toxicity Proto-Oncogene Proteins c-akt - metabolism Signal Transduction - drug effects |
| title | Bisphenol A disrupts glucose transport and neurophysiological role of IR/IRS/AKT/GSK3β axis in the brain of male mice |
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