Bisphenol A disrupts glucose transport and neurophysiological role of IR/IRS/AKT/GSK3β axis in the brain of male mice

Highlights • The associations of insulin signaling disruption and neurotoxicity were induced by BPA. • Exposure to BPA could interfere glucose uptake in CNS. • Hyperactivation of IR/AKT/GSK3β axis was showed in the brain of BPA treated mice. • Increase of phosphorylated tau and APP was observed in B...

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Veröffentlicht in:	Environmental toxicology and pharmacology 2016-04, Vol.43, p.7-12
Hauptverfasser:	Li, Jing, Wang, Yixin, Fang, Fangfang, Chen, Donglong, Gao, Yue, Liu, Jingli, Gao, Rong, Wang, Jun, Xiao, Hang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzhydryl Compounds - toxicity BPA Brain - drug effects Brain - physiology Emergency Endocrine Disruptors - toxicity Energy Metabolism - drug effects Glucose - metabolism Glucose Transport Proteins, Facilitative - metabolism Glucose transporters Glycogen Synthase Kinase 3 beta - metabolism Homeostasis - drug effects Insulin signaling Male Mice Neurodegenerative diseases Phenols - toxicity Proto-Oncogene Proteins c-akt - metabolism Signal Transduction - drug effects
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Zusammenfassung:	Highlights • The associations of insulin signaling disruption and neurotoxicity were induced by BPA. • Exposure to BPA could interfere glucose uptake in CNS. • Hyperactivation of IR/AKT/GSK3β axis was showed in the brain of BPA treated mice. • Increase of phosphorylated tau and APP was observed in BPA treated mice.
ISSN:	1382-6689 1872-7077
DOI:	10.1016/j.etap.2015.11.025