Desmethylanhydroicaritin isolated from Sophora flavescens , shows antitumor activities in U87MG cells via inhibiting the proliferation, migration and invasion

Highlights • DMAI showed cytotoxicity on U87MG cells. • DMAI inhibited MAPK/ERK and PI3 K/Akt/mTOR pathway. • DMAI induced morphological change and inhibition of filapodia formation. • DMAI led to down-regulation of migration and invasion of U87MG cells. • DMAI has the therapeutic potential for trea...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Environmental toxicology and pharmacology 2016-04, Vol.43, p.140-148
Hauptverfasser:	Kang, Chang-Won, Kim, Nan-Hee, Jung, Huyn Ah, Choi, Hyung-Wook, Kang, Min-Jae, Choi, Jae-Sue, Kim, Gun-Do
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Phytogenic - pharmacology Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Desmethylanhydroicaritin Emergency Flavones - pharmacology Humans Invasion Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 Migration Mitogen-activated protein kinase Neoplasm Invasiveness Phosphatidylinositol 3-Kinases - metabolism Proliferation Proto-Oncogene Proteins c-akt - metabolism Sophora TOR Serine-Threonine Kinases U87MG
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • DMAI showed cytotoxicity on U87MG cells. • DMAI inhibited MAPK/ERK and PI3 K/Akt/mTOR pathway. • DMAI induced morphological change and inhibition of filapodia formation. • DMAI led to down-regulation of migration and invasion of U87MG cells. • DMAI has the therapeutic potential for treating human glioblastoma.
ISSN:	1382-6689 1872-7077
DOI:	10.1016/j.etap.2016.03.003