Encouraging results for PD-1 inhibition in gastric cancer

Encouraging results for PD-1 inhibition in gastric cancer

[...]it is unclear whether the radiological responses that have been reported in seemingly PD-L1-negative patients treated with anti-PD1 therapies in non-biomarker selected trials are indicative of underlying heterogeneity of biomarker expression or a true absence of association between the biomarke...

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Veröffentlicht in:The lancet oncology 2016-06, Vol.17 (6), p.682-683
Hauptverfasser: Smyth, Elizabeth C, Cunningham, David
Format: Artikel
Sprache:eng
Schlagworte:
Biomarkers
Biomedical research
Cancer therapies
Chemotherapy
Clinical trials
Gastric cancer
Gene expression
Hematology, Oncology and Palliative Medicine
Immunotherapy
Medical prognosis
Medical research
Melanoma
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Zusammenfassung:[...]it is unclear whether the radiological responses that have been reported in seemingly PD-L1-negative patients treated with anti-PD1 therapies in non-biomarker selected trials are indicative of underlying heterogeneity of biomarker expression or a true absence of association between the biomarker and response.7 Further exploration will be needed to identify the best method to assess PD-L1 and whether it is a true predictive biomarker for immunotherapy in gastric cancer.
ISSN:1470-2045
1474-5488
DOI:10.1016/S1470-2045(16)30094-8