Distinct mechanisms of the newborn innate immunity

Distinct mechanisms of the newborn innate immunity

Highlights • Newborn immune-protection depends mainly on passive transfer of Immunoglobulin G from mother. • The innate and adaptive immunity in newborns is relatively naïve. • The immune responses in newborns can be improved using additional co-stimulatory agents. • Newborns are biased against the...

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Veröffentlicht in:Immunology letters 2016-05, Vol.173, p.42-54
Hauptverfasser: Kumar, Kingsley Manoj S, Bhat, B. Vishnu
Format: Artikel
Sprache:eng
Schlagworte:
Adaptive Immunity
Allergy and Immunology
Animals
Animals, Newborn
Cytokines - metabolism
Humans
Immune response
Immune Tolerance
Immunity, Innate
Immunity, Maternally-Acquired
Immunoglobulin G - immunology
Infant, Newborn
Innate immunity
Microbiome
Newborns
Pro-inflammatory cytokines
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Beschreibung
Zusammenfassung:Highlights • Newborn immune-protection depends mainly on passive transfer of Immunoglobulin G from mother. • The innate and adaptive immunity in newborns is relatively naïve. • The immune responses in newborns can be improved using additional co-stimulatory agents. • Newborns are biased against the production of pro-inflammatory cytokines. • Understanding the immunological mechanisms in a newborn could help improve protection against infections.
ISSN:0165-2478
1879-0542
DOI:10.1016/j.imlet.2016.03.009