Biogenesis of micronuclei

The presence of micronuclei in a cell is an indicator of DNA damage and genetic instability. In this review, mechanisms of emergence of micronuclei, their functional activity, and pathways of elimination are discussed. It is supposed that morphological and functional varieties of micronuclei as well...

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Veröffentlicht in:	Biochemistry (Moscow) 2016-05, Vol.81 (5), p.453-464
Hauptverfasser:	Kisurina-Evgenieva, O. P., Sutiagina, O. I., Onishchenko, G. E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Biosynthesis Cell Nucleus - chemistry Cell Nucleus - genetics Cell Nucleus - metabolism Deoxyribonucleic acid DNA DNA Damage - drug effects DNA Damage - radiation effects DNA Repair Gamma Rays Genetics Heterochromatin - chemistry Heterochromatin - metabolism Humans Interphase Life Sciences Microbiology Mutagens - toxicity Nuclear Envelope - metabolism Reactive Oxygen Species - metabolism Reviews
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Beschreibung
Zusammenfassung:	The presence of micronuclei in a cell is an indicator of DNA damage and genetic instability. In this review, mechanisms of emergence of micronuclei, their functional activity, and pathways of elimination are discussed. It is supposed that morphological and functional varieties of micronuclei as well as their degradation pathways can be determined by the chromosomal material localized inside these cell structures.
ISSN:	0006-2979 1608-3040
DOI:	10.1134/S0006297916050035