Single nucleotide polymorphisms in two genes among the Jarawa, a primitive tribe of the Andaman and Nicobar Islands

Single nucleotide polymorphisms in two genes among the Jarawa, a primitive tribe of the Andaman and Nicobar Islands

Discovery and validation of single nucleotide polymorphisms (SNPs) in the human genome is an active area of interest, because of their usefulness in evolutionary and disease-association studies. We have resequenced 70 chromosomes from the Jarawa, a Negrito tribal group inhabiting the Andaman and Nic...

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Veröffentlicht in:Current science (Bangalore) 2004-01, Vol.86 (2), p.326-328
Hauptverfasser: Singh, Sunita, Sengupta, Sanghamitra, Murhekar, Kanchan M., Sehgal, Subhash C., Majumder, Partha P.
Format: Artikel
Sprache:eng
Schlagworte:
Genes
Genetic variation
Genomics
Haplotypes
India, Andaman and Nicobar Is
Infectious diseases
Medical research
Nucleotides
Population genetics
RESEARCH COMMUNICATIONS
Single nucleotide polymorphism
Tumor necrosis factors
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Zusammenfassung:Discovery and validation of single nucleotide polymorphisms (SNPs) in the human genome is an active area of interest, because of their usefulness in evolutionary and disease-association studies. We have resequenced 70 chromosomes from the Jarawa, a Negrito tribal group inhabiting the Andaman and Nicobar archipelago, for a ≈ 10 kb genomic region spanning two genes, ICAM1 and TNF-α. We have discovered three new SNPs in the TNF-α gene. There is low sequence variability among the Jarawa, possibly due to founder effect and genetic drift.
ISSN:0011-3891