Accelerator-based production of the (99m)Tc-(186)Re diagnostic-therapeutic pair using metal disulfide targets (MoS2, WS2, OsS2)

Novel, natural abundance metal disulfide targets were irradiated for 1h with a 10µA proton beam in a small, medical cyclotron. Osmium disulfide was synthesized by simple distillation and precipitation methods while MoS2 and WS2 were commercially available. The targets dissolved under mild conditions...

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Veröffentlicht in:	Applied radiation and isotopes 2016-08, Vol.114, p.159-166
Hauptverfasser:	Gott, Matthew D, Hayes, Connor R, Wycoff, Donald E, Balkin, Ethan R, Smith, Bennett E, Pauzauskie, Peter J, Fassbender, Michael E, Cutler, Cathy S, Ketring, Alan R, Wilbur, D Scott, Jurisson, Silvia S
Format:	Artikel
Sprache:	eng
Schlagworte:	Cyclotrons Disulfides - radiation effects Humans Molybdenum - radiation effects Osmium Compounds - radiation effects Protons Radioisotopes - isolation & purification Radiopharmaceuticals - isolation & purification Rhenium - isolation & purification Spectrometry, Gamma Technetium - isolation & purification Tungsten Compounds - radiation effects
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Beschreibung
Zusammenfassung:	Novel, natural abundance metal disulfide targets were irradiated for 1h with a 10µA proton beam in a small, medical cyclotron. Osmium disulfide was synthesized by simple distillation and precipitation methods while MoS2 and WS2 were commercially available. The targets dissolved under mild conditions and were analyzed by γ-spectroscopy. Production rates and potential applications are discussed, including target recovery and recycling schemes for OsS2 and WS2.
ISSN:	1872-9800
DOI:	10.1016/j.apradiso.2016.05.024