The effect of N-acetylcysteine and calcium hydroxide on TNF-α and TGF-β1 in lipopolysaccharide-activated macrophages

Highlights • The pro- and anti-inflammatory properties of NAC and Ca (OH)2 were evaluated. • LPS-stimulated and LPS-unstimulated macrophage cell lines were used. • NAC down-regulated the TNF-α and TGF-β1 protein and gene levels. • NAC can be considered as an alternative to Ca (OH)2 medicament....

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Veröffentlicht in:	Archives of oral biology 2016-08, Vol.68, p.48-54
Hauptverfasser:	Karapinar, Senem Pinar, Ulum, Yeliz Zulfiye Akkaya, Ozcelik, Bahar, Buzoglu, Hatice Dogan, Ceyhan, Deniz, Peynircioglu, Banu Balci, Aksoy, Yasemin
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - pharmacology Advanced Basic Science Anti-Inflammatory Agents - pharmacology Calcium hydroxide Calcium Hydroxide - pharmacology Cell Death - drug effects Cell Line Cytokines Dentistry Endodontics Enzyme-Linked Immunosorbent Assay - methods Flow Cytometry Humans Inflammation Lipopolysaccharides - pharmacology Macrophages - cytology Macrophages - drug effects Macrophages - metabolism Monocytes - cytology Monocytes - drug effects Monocytes - metabolism N-Acetyl cysteine Real-Time Polymerase Chain Reaction - methods RNA, Messenger - genetics RNA, Messenger - metabolism Transforming Growth Factor beta1 - genetics Transforming Growth Factor beta1 - metabolism Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism
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Zusammenfassung:	Highlights • The pro- and anti-inflammatory properties of NAC and Ca (OH)2 were evaluated. • LPS-stimulated and LPS-unstimulated macrophage cell lines were used. • NAC down-regulated the TNF-α and TGF-β1 protein and gene levels. • NAC can be considered as an alternative to Ca (OH)2 medicament.
ISSN:	0003-9969 1879-1506
DOI:	10.1016/j.archoralbio.2016.03.017