Sam68 affects cell proliferation and apoptosis of human adult T-acute lymphoblastic leukemia cells via AKT/mTOR signal pathway

Highlights • Sam68 was upregulated in adult T-ALL patients’ samples and T cells. • Sam68 knockdown impaired proliferation, induced apoptosis and cycle arrest in T-ALL cells. • Sam68 knockdown downregulated CDK2, Bcl-xl and upregulated p21, Bad, cleaved caspase-9, caspase-3, PARP. • Sam68 knockdown a...

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Veröffentlicht in:	Leukemia research 2016-07, Vol.46, p.1-9
Hauptverfasser:	Wang, Qi, Li, Yuanye, Cheng, Jingying, Chen, Long, Xu, Hua, Li, Qinghua, Pang, Tianxiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - physiology Adult AKT/mTOR signaling pathway Apoptosis Cell Line, Tumor Cell Proliferation DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology Female Gene Expression Regulation, Leukemic Gene Knockdown Techniques Hematology, Oncology and Palliative Medicine Humans Male Middle Aged Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - pathology Proliferation Proto-Oncogene Proteins c-akt - metabolism RNA-Binding Proteins - genetics RNA-Binding Proteins - physiology Sam68 Signal Transduction T-cell acute lymphoblastic leukemia TOR Serine-Threonine Kinases - metabolism Tumor Cells, Cultured
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Zusammenfassung:	Highlights • Sam68 was upregulated in adult T-ALL patients’ samples and T cells. • Sam68 knockdown impaired proliferation, induced apoptosis and cycle arrest in T-ALL cells. • Sam68 knockdown downregulated CDK2, Bcl-xl and upregulated p21, Bad, cleaved caspase-9, caspase-3, PARP. • Sam68 knockdown associated with changes in AKT/mTOR signaling pathway. • Sam68 expression restoration reverted the above effects.
ISSN:	0145-2126 1873-5835
DOI:	10.1016/j.leukres.2016.04.011