The mesentery in Crohnʼs disease: friend or foe?

The mesentery in Crohnʼs disease: friend or foe?

PURPOSE OF REVIEWThis article assesses the role of the mesentery in Crohnʼs disease. RECENT FINDINGSThe mesentery is centrally positioned both anatomically and physiologically. Overlapping mesenteric and submucosal mesenchymal contributions are important in the pathobiology of Crohnʼs disease. Mesen...

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Veröffentlicht in:Current opinion in gastroenterology 2016-07, Vol.32 (4), p.267-273
Hauptverfasser: Coffey, John Calvin, O‘Leary, Donal Peter, Kiernan, Miranda G, Faul, Peter
Format: Artikel
Sprache:eng
Schlagworte:
Colonoscopy - methods
Crohn Disease - pathology
Crohn Disease - surgery
Humans
Mesentery - pathology
Mesentery - surgery
Postoperative Complications - prevention & control
Recurrence
Risk Factors
Secondary Prevention
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Zusammenfassung:PURPOSE OF REVIEWThis article assesses the role of the mesentery in Crohnʼs disease. RECENT FINDINGSThe mesentery is centrally positioned both anatomically and physiologically. Overlapping mesenteric and submucosal mesenchymal contributions are important in the pathobiology of Crohnʼs disease. Mesenteric contributions explain the topographic distribution of Crohnʼs disease in general and mucosal disease in particular. Operative strategies that are mesenteric based (i.e. mesocolic excision) may reduce rates of postoperative recurrence. SUMMARYThe net effect of mesenteric events in Crohnʼs disease is pathologic. This can be targeted by operative means. VIDEO ABSTRACThttp://links.lww.com/COG/A18.
ISSN:0267-1379
1531-7056
DOI:10.1097/MOG.0000000000000280