Biomarker discovery using dry-lab technologies and high-throughput screening

Cerebrospinal fluid is a rational biopsy for detecting brain-disease biomarkers (4). [...]high-throughput technology provides a powerful tool with which to facilitate biomarker identification regardless of whether the sample is plasma, serum or cerebrospinal fluid. Using a combination of serum assays, mass spectrometry and computational modeling, Wang's group identified a combined-biomarker panel based on analysis of 10 serum molecules and 6 mass spectra peaks, and this approach reached 87% accuracy. [...]X Xie (Zhejiang University in China) evaluated platelet distribution width in patients with chronic obstructive pulmonary diseases who also had a pulmonary embolism.