Ozone exposure induces iNOS expression and tyrosine nitration in rat aorta

Ozone exposure induces iNOS expression and tyrosine nitration in rat aorta

The aim was to study whether ozone affects vascular endothelium by causing inducible nitric oxide synthase (iNOS) expression and tyrosine nitration. We also studied biomarkers of endothelial function. Male Wistar rats were exposed to ozone (0.25 ppm, 4 h/day) or filtered air (control, ozone

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Veröffentlicht in:Environmental toxicology and pharmacology 2004-05, Vol.17 (1), p.1-7
Hauptverfasser: Sánchez-González, Dolores J, Moro, Marı́a A, Castillo-Henkel, Carlos, Herrera-González, Norma, Hernández-Pando, Rogelio, Larios-Medina, Francisco J, Cobilt, Rafael, Blanco, José A, Pedraza-Chaverrı́, José, Villanueva, Cleva
Format: Artikel
Sprache:eng
Schlagworte:
Endothelial dysfunction
Oxidative stress
Ozone
Peroxynitrite
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Zusammenfassung:The aim was to study whether ozone affects vascular endothelium by causing inducible nitric oxide synthase (iNOS) expression and tyrosine nitration. We also studied biomarkers of endothelial function. Male Wistar rats were exposed to ozone (0.25 ppm, 4 h/day) or filtered air (control, ozone
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2004.01.002