Stearoyl-CoA Desaturase 1 Deficiency Increases Fatty Acid Oxidation by Activating AMP-Activated Protein Kinase in Liver

Stearoyl-CoA desaturase (SCD) catalyzes the rate-limiting step in the biosynthesis of monounsaturated fatty acids. Mice with a targeted disruption of the SCD1 isoform have reduced body adiposity, increased energy expenditure, and up-regulated expression of several genes encoding enzymes of fatty aci...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 2004-04, Vol.101 (17), p.6409-6414
Hauptverfasser: Dobrzyn, Pawel, Dobrzyn, Agnieszka, Miyazaki, Makoto, Cochen, Paul, Asilmaz, Esra, Hardie, D. Grahame, Friedman, Jeffrey M., Ntambi, James M., Lardy, Henry
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Sprache:eng
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Zusammenfassung:Stearoyl-CoA desaturase (SCD) catalyzes the rate-limiting step in the biosynthesis of monounsaturated fatty acids. Mice with a targeted disruption of the SCD1 isoform have reduced body adiposity, increased energy expenditure, and up-regulated expression of several genes encoding enzymes of fatty acid β-oxidation in liver. The mechanisms by which SCD deficiency leads to these metabolic changes are presently unknown. Here we show that the phosphorylation and activity of AMP-activated protein kinase (AMPK), a metabolic sensor that regulates lipid metabolism during increased energy expenditure is significantly increased (≈40%, P
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.0401627101