Stearoyl-CoA Desaturase 1 Deficiency Increases Fatty Acid Oxidation by Activating AMP-Activated Protein Kinase in Liver
Stearoyl-CoA desaturase (SCD) catalyzes the rate-limiting step in the biosynthesis of monounsaturated fatty acids. Mice with a targeted disruption of the SCD1 isoform have reduced body adiposity, increased energy expenditure, and up-regulated expression of several genes encoding enzymes of fatty aci...
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Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2004-04, Vol.101 (17), p.6409-6414 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Stearoyl-CoA desaturase (SCD) catalyzes the rate-limiting step in the biosynthesis of monounsaturated fatty acids. Mice with a targeted disruption of the SCD1 isoform have reduced body adiposity, increased energy expenditure, and up-regulated expression of several genes encoding enzymes of fatty acid β-oxidation in liver. The mechanisms by which SCD deficiency leads to these metabolic changes are presently unknown. Here we show that the phosphorylation and activity of AMP-activated protein kinase (AMPK), a metabolic sensor that regulates lipid metabolism during increased energy expenditure is significantly increased (≈40%, P |
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ISSN: | 0027-8424 1091-6490 |
DOI: | 10.1073/pnas.0401627101 |