Applications of RNA interference for studies in DNA damage processing, genome stability, mutagenesis, and cancer

Applications of RNA interference for studies in DNA damage processing, genome stability, mutagenesis, and cancer

RNA interference, discovered only five years ago, is an important system for the control of gene expression. It is also quickly becoming a valuable experimental tool as it allows investigators to knock down the level of expression of specific genes. In this paper, we review some applications of this...

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Veröffentlicht in:Seminars in cancer biology 2003-08, Vol.13 (4), p.301-308
Hauptverfasser: Bedford, Joel S, Liber, Howard L
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biological and medical sciences
DNA Damage
DNA Repair
Gene Expression Regulation
Genome
Genome stability
Humans
Medical sciences
Mutagenesis
Neoplasms - genetics
RNA Interference
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Zusammenfassung:RNA interference, discovered only five years ago, is an important system for the control of gene expression. It is also quickly becoming a valuable experimental tool as it allows investigators to knock down the level of expression of specific genes. In this paper, we review some applications of this technology for studies in DNA damage processing, genome stability, mutagenesis, and cancer.
ISSN:1044-579X
1096-3650
DOI:10.1016/S1044-579X(03)00044-0