Differences in Bordetella pertussis DNA load according to clinical and epidemiological characteristics of patients with whooping cough
Summary Objective To identify associations between nasopharyngeal Bordetella pertussis DNA load and clinical and epidemiological characteristics and evaluate DNA load prognostic value in pertussis severity. Methods Prospective observational multi-centre study including nasopharyngeal samples positiv...
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Veröffentlicht in: | The Journal of infection 2016-04, Vol.72 (4), p.460-467 |
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Hauptverfasser: | , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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Zusammenfassung: | Summary Objective To identify associations between nasopharyngeal Bordetella pertussis DNA load and clinical and epidemiological characteristics and evaluate DNA load prognostic value in pertussis severity. Methods Prospective observational multi-centre study including nasopharyngeal samples positive to pertussis DNA by real-time PCR collected from children and adult patients in more than 200 health centres of Catalonia (Spain) during 2012–2013. Results B. pertussis load was inversely correlated with age (rho = −0.32, p |
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ISSN: | 0163-4453 1532-2742 |
DOI: | 10.1016/j.jinf.2016.01.013 |