Differences in Bordetella pertussis DNA load according to clinical and epidemiological characteristics of patients with whooping cough

Summary Objective To identify associations between nasopharyngeal Bordetella pertussis DNA load and clinical and epidemiological characteristics and evaluate DNA load prognostic value in pertussis severity. Methods Prospective observational multi-centre study including nasopharyngeal samples positiv...

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Veröffentlicht in:The Journal of infection 2016-04, Vol.72 (4), p.460-467
Hauptverfasser: Brotons, Pedro, de Paz, Hector D, Toledo, Diana, Villanova, Marta, Plans, Pedro, Jordan, Iolanda, Dominguez, Angela, Jane, Mireia, Godoy, Pere, Muñoz-Almagro, Carmen
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Sprache:eng
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Zusammenfassung:Summary Objective To identify associations between nasopharyngeal Bordetella pertussis DNA load and clinical and epidemiological characteristics and evaluate DNA load prognostic value in pertussis severity. Methods Prospective observational multi-centre study including nasopharyngeal samples positive to pertussis DNA by real-time PCR collected from children and adult patients in more than 200 health centres of Catalonia (Spain) during 2012–2013. Results B. pertussis load was inversely correlated with age (rho = −0.32, p  
ISSN:0163-4453
1532-2742
DOI:10.1016/j.jinf.2016.01.013