Incidence of and risk factors for severe acute kidney injury in children with heart failure treated with renin–angiotensin system inhibitors

Incidence of and risk factors for severe acute kidney injury in children with heart failure treated with renin–angiotensin system inhibitors

No large cohort study has yet determined the incidence of acute kidney injury (AKI) in children with heart failure treated with renin–angiotensin system (RAS) inhibitors. We thus retrospectively analyzed the incidence and risk factors for severe AKI (stages 2–3 according to the Kidney Disease Improv...

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Veröffentlicht in:European journal of pediatrics 2016-05, Vol.175 (5), p.631-637
Hauptverfasser: Terano, Chikako, Ishikura, Kenji, Miura, Masaru, Hamada, Riku, Harada, Ryoko, Sakai, Tomoyuki, Hamasaki, Yuko, Hataya, Hiroshi, Ando, Takashi, Honda, Masataka
Format: Artikel
Sprache:eng
Schlagworte:
Acidosis
Acute Kidney Injury - diagnosis
Acute Kidney Injury - epidemiology
Acute Kidney Injury - etiology
Adolescent
Angiotensin II Type 1 Receptor Blockers - therapeutic use
Angiotensin-Converting Enzyme Inhibitors - therapeutic use
Cardiovascular disease
Child
Child, Preschool
Cohort analysis
Congenital diseases
Data collection
Enzymes
Ethics
Female
Follow-Up Studies
Glomerular Filtration Rate - drug effects
Heart failure
Heart Failure - complications
Heart Failure - drug therapy
Heart surgery
Humans
Hyperkalemia
Incidence
Infant
Japan - epidemiology
Kidney diseases
Male
Medicine
Medicine & Public Health
Metabolism
Nephrology
Original Article
Pediatrics
Prognosis
Renin-Angiotensin System - drug effects
Retrospective Studies
Risk Factors
Time Factors
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Zusammenfassung:No large cohort study has yet determined the incidence of acute kidney injury (AKI) in children with heart failure treated with renin–angiotensin system (RAS) inhibitors. We thus retrospectively analyzed the incidence and risk factors for severe AKI (stages 2–3 according to the Kidney Disease Improving Global Outcomes (KDIGO) guidelines) at our institutions from 2008 to 2011. Among 312 children (162 boys; median age, 7.3 months), 59 cases of AKI occurred in 45 children. The incidence of AKI was 14.3 cases per 100 person-years overall (follow-up 413.6 person-years), or 27.3, 16.8, and 4.5 cases per 100 person-years in children aged
ISSN:0340-6199
1432-1076
DOI:10.1007/s00431-015-2680-8