Targeted nano-delivery of novel omega-3 conjugate against hepatocellular carcinoma: Regulating COX-2/bcl-2 expression in an animal model

Highlights • Preparation and characterization of diisopropylphenol-linolenic acid conjugate entrapped liposomal nano-formulation. • Assessment of anticancer potential of nano-formulation against liver cancer. • The conjugate was able to inhibit proliferation, adhesion and migration of HepG2 cancer c...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2016-07, Vol.81, p.394-401
Hauptverfasser:	Khan, Azmat Ali, Alanazi, Amer M, Jabeen, Mumtaz, Hassan, Iftekhar, Bhat, Mashooq Ahmad
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Annexin A5 - metabolism Anticancer agent Antineoplastic Agents - pharmacology Apoptosis - drug effects Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - pathology Cell Adhesion - drug effects Cell Movement - drug effects Cyclooxygenase 2 - metabolism Disease Models, Animal Drug Delivery Systems - methods Hep G2 Cells Humans Immunoblotting Internal Medicine Kinetics Linoleic Acids, Conjugated - pharmacology Linoleic Acids, Conjugated - therapeutic use Linolenic acid Liver cancer Liver Neoplasms - drug therapy Liver Neoplasms - pathology Male Medical Education Mice Nano-formulation Nanoparticles - chemistry Nanoparticles - ultrastructure Omega-3 conjugate Particle Size Proto-Oncogene Proteins c-bcl-2 - metabolism Static Electricity Survival Analysis
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Zusammenfassung:	Highlights • Preparation and characterization of diisopropylphenol-linolenic acid conjugate entrapped liposomal nano-formulation. • Assessment of anticancer potential of nano-formulation against liver cancer. • The conjugate was able to inhibit proliferation, adhesion and migration of HepG2 cancer cells. • The nano-formulation modulated expression of COX-2, bcl-2 and Bax resulting in apoptosis of liver cancer cells in mice.
ISSN:	0753-3322 1950-6007
DOI:	10.1016/j.biopha.2016.04.033