Luteinizing hormone/chorionic gonadotrophin receptor overexpressed in granulosa cells from polycystic ovary syndrome ovaries is functionally active
Highlights • LHCGR expression and activity are increased in GCs from PCOS patients. • ARF6 small GTPase is highly expressed in PCOS GCs. • HCG-stimulation increased the levels of active form of ARF6. • ARF6 activation inhibitors reduced LHCGR internalisation in normal and PCOS GCs. • HCG-induced HLH...
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| Veröffentlicht in: | Reproductive biomedicine online 2016-06, Vol.32 (6), p.635-641 |
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| container_title | Reproductive biomedicine online |
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| creator | Kanamarlapudi, Venkateswarlu Gordon, Uma D López Bernal, Andrés |
| description | Highlights • LHCGR expression and activity are increased in GCs from PCOS patients. • ARF6 small GTPase is highly expressed in PCOS GCs. • HCG-stimulation increased the levels of active form of ARF6. • ARF6 activation inhibitors reduced LHCGR internalisation in normal and PCOS GCs. • HCG-induced HLHCGR internalisation is unaltered in PCOS GCs. |
| doi_str_mv | 10.1016/j.rbmo.2016.03.003 |
| format | Article |
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Gordon, Uma D ; López Bernal, Andrés</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c521t-f0a2784487425be61a6a9c3171e1fb76bd75452dbac8911661ec2cd3c3690bab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>ADP-Ribosylation Factor 6</topic><topic>ADP-Ribosylation Factors - metabolism</topic><topic>ARF6</topic><topic>cAMP</topic><topic>Chorionic Gonadotropin - metabolism</topic><topic>Cyclic AMP - metabolism</topic><topic>Female</topic><topic>Follicular Fluid - metabolism</topic><topic>Granulosa Cells - cytology</topic><topic>GTP Phosphohydrolases - chemistry</topic><topic>human granulosa cells</topic><topic>Humans</topic><topic>LHCGR</topic><topic>Lutein - chemistry</topic><topic>Luteinizing Hormone - metabolism</topic><topic>Obstetrics and Gynecology</topic><topic>Ovarian Follicle - metabolism</topic><topic>Ovary - metabolism</topic><topic>Ovulation - metabolism</topic><topic>PCOS</topic><topic>Polycystic Ovary Syndrome - metabolism</topic><topic>Receptors, LH - metabolism</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kanamarlapudi, Venkateswarlu</creatorcontrib><creatorcontrib>Gordon, Uma D</creatorcontrib><creatorcontrib>López Bernal, Andrés</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Reproductive biomedicine online</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kanamarlapudi, Venkateswarlu</au><au>Gordon, Uma D</au><au>López Bernal, Andrés</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Luteinizing hormone/chorionic gonadotrophin receptor overexpressed in granulosa cells from polycystic ovary syndrome ovaries is functionally active</atitle><jtitle>Reproductive biomedicine online</jtitle><addtitle>Reprod Biomed Online</addtitle><date>2016-06-01</date><risdate>2016</risdate><volume>32</volume><issue>6</issue><spage>635</spage><epage>641</epage><pages>635-641</pages><issn>1472-6483</issn><eissn>1472-6491</eissn><abstract>Highlights • LHCGR expression and activity are increased in GCs from PCOS patients. • ARF6 small GTPase is highly expressed in PCOS GCs. • HCG-stimulation increased the levels of active form of ARF6. • ARF6 activation inhibitors reduced LHCGR internalisation in normal and PCOS GCs. • HCG-induced HLHCGR internalisation is unaltered in PCOS GCs.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>27061682</pmid><doi>10.1016/j.rbmo.2016.03.003</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-8739-1483</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Reproductive biomedicine online, 2016-06, Vol.32 (6), p.635-641 |
| issn | 1472-6483 1472-6491 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | ADP-Ribosylation Factor 6 ADP-Ribosylation Factors - metabolism ARF6 cAMP Chorionic Gonadotropin - metabolism Cyclic AMP - metabolism Female Follicular Fluid - metabolism Granulosa Cells - cytology GTP Phosphohydrolases - chemistry human granulosa cells Humans LHCGR Lutein - chemistry Luteinizing Hormone - metabolism Obstetrics and Gynecology Ovarian Follicle - metabolism Ovary - metabolism Ovulation - metabolism PCOS Polycystic Ovary Syndrome - metabolism Receptors, LH - metabolism Time Factors |
| title | Luteinizing hormone/chorionic gonadotrophin receptor overexpressed in granulosa cells from polycystic ovary syndrome ovaries is functionally active |
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