Luteinizing hormone/chorionic gonadotrophin receptor overexpressed in granulosa cells from polycystic ovary syndrome ovaries is functionally active

Highlights • LHCGR expression and activity are increased in GCs from PCOS patients. • ARF6 small GTPase is highly expressed in PCOS GCs. • HCG-stimulation increased the levels of active form of ARF6. • ARF6 activation inhibitors reduced LHCGR internalisation in normal and PCOS GCs. • HCG-induced HLH...

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Veröffentlicht in:	Reproductive biomedicine online 2016-06, Vol.32 (6), p.635-641
Hauptverfasser:	Kanamarlapudi, Venkateswarlu, Gordon, Uma D, López Bernal, Andrés
Format:	Artikel
Sprache:	eng
Schlagworte:	ADP-Ribosylation Factor 6 ADP-Ribosylation Factors - metabolism ARF6 cAMP Chorionic Gonadotropin - metabolism Cyclic AMP - metabolism Female Follicular Fluid - metabolism Granulosa Cells - cytology GTP Phosphohydrolases - chemistry human granulosa cells Humans LHCGR Lutein - chemistry Luteinizing Hormone - metabolism Obstetrics and Gynecology Ovarian Follicle - metabolism Ovary - metabolism Ovulation - metabolism PCOS Polycystic Ovary Syndrome - metabolism Receptors, LH - metabolism Time Factors
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Zusammenfassung:	Highlights • LHCGR expression and activity are increased in GCs from PCOS patients. • ARF6 small GTPase is highly expressed in PCOS GCs. • HCG-stimulation increased the levels of active form of ARF6. • ARF6 activation inhibitors reduced LHCGR internalisation in normal and PCOS GCs. • HCG-induced HLHCGR internalisation is unaltered in PCOS GCs.
ISSN:	1472-6483 1472-6491
DOI:	10.1016/j.rbmo.2016.03.003