Does low-normal serum TSH level adversely impact cognition in elderly adults and might methimazole therapy improve outcomes?

Serum thyroid stimulating hormone (TSH) levels increase with age. This elevation has been associated with better outcomes in very elderly subjects; however, little is known about the relationship between TSH below the lower limit of the reference range and health-related outcomes. Here, we investiga...

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Veröffentlicht in:	ENDOCRINE JOURNAL 2016, Vol.63(5), pp.495-505
Hauptverfasser:	Dhiãnah Santini de Oliveira Chachamovitz, Vigário, Patrícia dos Santos, Silva, Silvana Oliveira e, Letícia B. B. de Mello Teixeira, Fagundes, Michele Lopes, Vaisman, Mário, Patrícia de F. dos S. Teixeira
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Aging - blood Cognition Cognition - drug effects Cognition Disorders - blood Cognition Disorders - drug therapy Cross-Sectional Studies Depression Depression - blood Elderly Female Geriatric Assessment Humans Longitudinal Studies Male Methimazole - therapeutic use Pilot Projects Reference Values Thyroid Function Tests - standards Thyrotropin - blood TSH
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Zusammenfassung:	Serum thyroid stimulating hormone (TSH) levels increase with age. This elevation has been associated with better outcomes in very elderly subjects; however, little is known about the relationship between TSH below the lower limit of the reference range and health-related outcomes. Here, we investigated the association between cognitive impairment or depressive symptoms and low-normal serum TSH (
ISSN:	0918-8959 1348-4540
DOI:	10.1507/endocrj.EJ15-0458