NUCLEAR AND MITOCHONDRIAL TRANSLOCATION OF PHOSPHORYLATED PKC Delta ASSOCIATES WITH TUNEL-POSITIVE AND UROCORTIN NEGATIVE STAINING IN THE HUMAN HEART FROM DIABETIC PATIENTS UNDERGOING ON-PUMP CARDIAC SURGERY

Aim: Molecular mechanisms responsible for the reported worse outcome of diabetic patients (DMP) after on-pump cardiac surgery (OPCS) remain unknown. Opposite effects have been reported for Urocortin (Ucn)/PKC epsilon and PKC delta , the former being cardio-protective and the latter pro-apoptotic. We...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International journal of artificial organs 2014-01, Vol.37 (8), p.599-599
Hauptverfasser:	Chen-Scarabelli, C, Knight, R, Stephanou, A, Mccauley, R, Saravolatz, L II, Onorati, F, Tessari, M, Rungatscher, A, Latchman, D, Abbasciano, R, Saravolatz, L, Mazzucco, A, Scarabelli, T M, Faggian, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Artificial organs Human Patients Process control Proteins Relocation Surgery
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Aim: Molecular mechanisms responsible for the reported worse outcome of diabetic patients (DMP) after on-pump cardiac surgery (OPCS) remain unknown. Opposite effects have been reported for Urocortin (Ucn)/PKC epsilon and PKC delta , the former being cardio-protective and the latter pro-apoptotic. We investigated the role of PKC epsilon and PKC delta in Ucn-induced cardio-protection in DMP and non-diabetic patients (NDMP) after OPCS. Methods and Results: Two sequential biopsies were obtained from the right atrium of 27 DMP and 22 NDMP before Cardio-Pulmonary Bypass (CPB) and 10 minutes after declamping. In post-cardioplegic NDMP, Ucn was induced at both mRNA and protein levels (p
ISSN:	0391-3988
DOI:	10.5301/ijao.5000346