Measurement of Individual Nanobioparticles on Microfluidic Chips by Laser Dark-field Imaging
A microfluidic-chip-based analysis platform specially tuned for characterizing individual nanobio-particles has been developed. Using this platform, both artificial nanobioparticles (polyion complex vesicles) and cell-secreted exosomes with diameter down to 50 nm can be observed. The zeta potential...
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| Veröffentlicht in: | Journal of Photopolymer Science and Technology 2015/06/22, Vol.28(5), pp.727-730 |
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| container_end_page | 730 |
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| container_issue | 5 |
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| container_title | Journal of Photopolymer Science and Technology |
| container_volume | 28 |
| creator | Akagi, Takanori Hanamura, Nami Ichiki, Takanori |
| description | A microfluidic-chip-based analysis platform specially tuned for characterizing individual nanobio-particles has been developed. Using this platform, both artificial nanobioparticles (polyion complex vesicles) and cell-secreted exosomes with diameter down to 50 nm can be observed. The zeta potential distribution of the exosomes was obtained by measuring the zeta potential of individual exosomes. Since the number of surface molecules on nanobioparticles can be estimated by applying a particle immunoelectrophoresis method, this platform is promising for obtaining profiles of heterogeneous nanobioparticles including nanoDDS carriers and exosomes. |
| doi_str_mv | 10.2494/photopolymer.28.727 |
| format | Article |
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Using this platform, both artificial nanobioparticles (polyion complex vesicles) and cell-secreted exosomes with diameter down to 50 nm can be observed. The zeta potential distribution of the exosomes was obtained by measuring the zeta potential of individual exosomes. Since the number of surface molecules on nanobioparticles can be estimated by applying a particle immunoelectrophoresis method, this platform is promising for obtaining profiles of heterogeneous nanobioparticles including nanoDDS carriers and exosomes.</description><identifier>ISSN: 0914-9244</identifier><identifier>EISSN: 1349-6336</identifier><identifier>DOI: 10.2494/photopolymer.28.727</identifier><language>eng</language><publisher>Hiratsuka: The Society of Photopolymer Science and Technology(SPST)</publisher><subject>Carriers ; exosome ; laser dark-field imaging ; Lasers ; microfluidic chip ; Microfluidics ; nanobioparticle ; Nanostructure ; Photopolymers ; Platforms ; polyion complex vesicle (PICsome) ; Vesicles ; Zeta potential</subject><ispartof>Journal of Photopolymer Science and Technology, 2015/06/22, Vol.28(5), pp.727-730</ispartof><rights>2015 The Society of Photopolymer Science and Technology (SPST)</rights><rights>Copyright Japan Science and Technology Agency 2015</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c605t-3fee910f4899933702e42ea723c64999f8a47ed709e5ec2cb1257abe045fa63</citedby><cites>FETCH-LOGICAL-c605t-3fee910f4899933702e42ea723c64999f8a47ed709e5ec2cb1257abe045fa63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1882,27923,27924</link.rule.ids></links><search><creatorcontrib>Akagi, Takanori</creatorcontrib><creatorcontrib>Hanamura, Nami</creatorcontrib><creatorcontrib>Ichiki, Takanori</creatorcontrib><title>Measurement of Individual Nanobioparticles on Microfluidic Chips by Laser Dark-field Imaging</title><title>Journal of Photopolymer Science and Technology</title><addtitle>J. Photopol. Sci. Technol.</addtitle><description>A microfluidic-chip-based analysis platform specially tuned for characterizing individual nanobio-particles has been developed. Using this platform, both artificial nanobioparticles (polyion complex vesicles) and cell-secreted exosomes with diameter down to 50 nm can be observed. The zeta potential distribution of the exosomes was obtained by measuring the zeta potential of individual exosomes. Since the number of surface molecules on nanobioparticles can be estimated by applying a particle immunoelectrophoresis method, this platform is promising for obtaining profiles of heterogeneous nanobioparticles including nanoDDS carriers and exosomes.</description><subject>Carriers</subject><subject>exosome</subject><subject>laser dark-field imaging</subject><subject>Lasers</subject><subject>microfluidic chip</subject><subject>Microfluidics</subject><subject>nanobioparticle</subject><subject>Nanostructure</subject><subject>Photopolymers</subject><subject>Platforms</subject><subject>polyion complex vesicle (PICsome)</subject><subject>Vesicles</subject><subject>Zeta potential</subject><issn>0914-9244</issn><issn>1349-6336</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNplkM9LwzAUgIMoOKd_gZeAFy-daX60zVGm08HUgx6FkKUvW2bb1KQV9t9b2Riip8Dj-x4vH0KXKZlQLvlNu_adb321rSFMaDHJaX6ERinjMskYy47RiMiUJ5JyforOYtwQwpgQcoTen0DHPkANTYe9xfOmdF-u7HWFn3Xjl863OnTOVBCxb_CTM8HbqnelM3i6dm3Eyy1e6AgB3-nwkVgHVYnntV65ZnWOTqyuIlzs3zF6nd2_TR-TxcvDfHq7SExGRJcwCyBTYnkhpWQsJxQ4BZ1TZjI-jGyheQ5lTiQIMNQsUypyvQTChdUZG6Pr3dY2-M8eYqdqFw1UlW7A91GluWRUUlLQAb36g258H5rhtoESlKSCcD5QbEcNf40xgFVtcLUOW5US9dNb_e6taKGG3oM121mb2OkVHJx9vn-O2IsHwKx1UNCwb3VBki8</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Akagi, Takanori</creator><creator>Hanamura, Nami</creator><creator>Ichiki, Takanori</creator><general>The Society of Photopolymer Science and Technology(SPST)</general><general>Japan Science and Technology Agency</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SP</scope><scope>7SR</scope><scope>7U5</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20150101</creationdate><title>Measurement of Individual Nanobioparticles on Microfluidic Chips by Laser Dark-field Imaging</title><author>Akagi, Takanori ; Hanamura, Nami ; Ichiki, Takanori</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c605t-3fee910f4899933702e42ea723c64999f8a47ed709e5ec2cb1257abe045fa63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Carriers</topic><topic>exosome</topic><topic>laser dark-field imaging</topic><topic>Lasers</topic><topic>microfluidic chip</topic><topic>Microfluidics</topic><topic>nanobioparticle</topic><topic>Nanostructure</topic><topic>Photopolymers</topic><topic>Platforms</topic><topic>polyion complex vesicle (PICsome)</topic><topic>Vesicles</topic><topic>Zeta potential</topic><toplevel>online_resources</toplevel><creatorcontrib>Akagi, Takanori</creatorcontrib><creatorcontrib>Hanamura, Nami</creatorcontrib><creatorcontrib>Ichiki, Takanori</creatorcontrib><collection>CrossRef</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Journal of Photopolymer Science and Technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akagi, Takanori</au><au>Hanamura, Nami</au><au>Ichiki, Takanori</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Measurement of Individual Nanobioparticles on Microfluidic Chips by Laser Dark-field Imaging</atitle><jtitle>Journal of Photopolymer Science and Technology</jtitle><addtitle>J. Photopol. Sci. Technol.</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>28</volume><issue>5</issue><spage>727</spage><epage>730</epage><pages>727-730</pages><issn>0914-9244</issn><eissn>1349-6336</eissn><abstract>A microfluidic-chip-based analysis platform specially tuned for characterizing individual nanobio-particles has been developed. Using this platform, both artificial nanobioparticles (polyion complex vesicles) and cell-secreted exosomes with diameter down to 50 nm can be observed. The zeta potential distribution of the exosomes was obtained by measuring the zeta potential of individual exosomes. 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| ispartof | Journal of Photopolymer Science and Technology, 2015/06/22, Vol.28(5), pp.727-730 |
| issn | 0914-9244 1349-6336 |
| language | eng |
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| source | J-STAGE Free; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Carriers exosome laser dark-field imaging Lasers microfluidic chip Microfluidics nanobioparticle Nanostructure Photopolymers Platforms polyion complex vesicle (PICsome) Vesicles Zeta potential |
| title | Measurement of Individual Nanobioparticles on Microfluidic Chips by Laser Dark-field Imaging |
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