THE EFFECT OF LEFT VENTRICULAR ASSIST DEVICE SUPPORT ON CORONARY ARTERY BYPASS GRAFT USING COMPUTATIONAL STUDY

Aim: In order to enhance the patency rate of coronary arteries bypass graft (CABG) in the heart failure patient who supported with left ventricular assist device (LVAD), local hemodynamic profile was considered. The effect from LVAD support might modulate local flow condition which related to progressive atherosclerosis and intimal hyperplasia. Therefore, flow pattern and endothelial shear stress should be analysis. Methods: In this study, computational fluid dynamic was used to analyse three dimensional CABG (5:3 graft-to-host diameter ratios). Six end-to-side CABG configurations which consist of three patterns of the anastomotic angle (15, 30 and 45 degrees) and two patterns of the distance from a stenosis to the heel point of anastomosis (0 and 5 mm) were simulated. The flow measurements at diastolic phase of the acute animal experiment from the study of Y. Ootaki et al., 2005 during LVAD support at 2, 2.5 and 3 litre/min were used to impose at the proximal of graft and host vessels. The blood flow was assumed to be incompressible with Newtonian property at a viscosity of 0.004 kg m-s and a density of 1050 kg/m3. In this study the steady flow simulation were performed. Results: For increasing LVAD support, maximum shear stress at the toe of anastomosis were decrease and the area of low shear stress (