super(11)C-carbonylation reactions using gas-liquid segmented microfluidics

A novel gas-liquid segmented microfluidic platform has been developed. The Pd-mediated super(11)C-carbonylation reaction proceeds smoothly on this platform and good to excellent radiochemical conversions (RCC) were observed. Twelve compounds were successfully radiolabelled using this novel technolog...

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Veröffentlicht in:	RSC advances 2015-10, Vol.5 (108), p.88886-88889
Hauptverfasser:	Dahl, Kenneth, Schou, Magnus, Ulin, Johan, Sjoberg, Carl-Olof, Farde, Lars, Halldin, Christer
Format:	Artikel
Sprache:	eng
Schlagworte:	Conversion Microfluidics Palladium Platforms Receptors Technology utilization
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	A novel gas-liquid segmented microfluidic platform has been developed. The Pd-mediated super(11)C-carbonylation reaction proceeds smoothly on this platform and good to excellent radiochemical conversions (RCC) were observed. Twelve compounds were successfully radiolabelled using this novel technology, including the well established D sub(2) receptor radioligands [ super(11)C]raclopride and [ super(11)C]FLB 457.
ISSN:	2046-2069
DOI:	10.1039/c5ra20646d