Omega-3 fatty acids incorporated colloidal systems for the delivery of Angelica gigas Nakai extract

[Display omitted] •Colloidal carriers for Angelica gigas Nakai (AGN) ethanol extract were developed.•Omega-3 (ω-3)/Labrasol/TPGS/water-based oil-in-water microemulsion (ME) was prepared.•MEs provided the enhanced release of decursin and decursinol angelate.•Oral bioavailability of decursinol from ME group was higher than suspension group. Omega-3 (ω-3) fish oil-enriched colloidal systems were developed for the oral delivery of Angelica gigas Nakai (AGN) extract (ext). By constructing a pseudo-ternary phase diagram, the composition of oil-in-water (o/w) microemulsion (ME) systems based on ω-3 (oil), Labrasol (surfactant), and water was determined. AGN ext was dissolved into the ME system and d-α-tocopherol polyethylene glycol 1000 succinate (TPGS) was added to the ME formulation in order to enhance the mucosal absorption of the pharmacologically active ingredients in the AGN ext. The droplet size of AGN-loaded MEs was 205–277nm and their morphology was spherical. The release of major components of AGN, decursin (D) and decursinol angelate (DA), from ME formulations in pH 1.2 and 6.8 buffers was significantly greater (P