Dexketoprofen and aceclofenac release from layered double hydroxide and SBA-15 ordered mesoporous material

Two non-steroidal anti-inflammatory drugs, dexketoprofen (Dx) and aceclofenac (Ac), were incorporated in two different matrixes, layered double hydroxide and ordered mesoporous silica, SBA-15. The matrixes and the samples were characterized by different techniques, PXRD, SEM, TEM, FT-IR, N2 adsorption at −196°C and the drug release speed was also measured. The total amount of incorporated drug to the different matrixes was higher in the LDH than in mesoporous silica. The release studies showed a higher drug release speed from the layered double hydroxide than from the ordered mesoporous silica, but even so slower than the one found for the pure drugs, what shows that these solids can be used as drug controlled release matrixes. [Display omitted] •Dexketoprofen-LDH was synthesized by coprecipitation and ion-exchange methods.•The drug incorporation to the SBA-15 was made by impregnation method.•Both matrices (LDH and mesoporous silica) can be used as control release systems.•Drug molecules release faster from LDH than SBA-15.