Maniwamycins: new quorum-sensing inhibitors against Chromobacterium violaceum CV026 were isolated from Streptomyces sp. TOHO-M025

Quorum sensing is an important microbial signaling system that controls the expression of many virulence genes. Maniwamycins C–F, new compounds and quorum-sensing inhibitors, were isolated from the culture broth of Streptomyces sp. TOHO-M025 using a silica gel column and preparative HPLC. The struct...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of antibiotics 2016-05, Vol.69 (5), p.395-399
Hauptverfasser:	Fukumoto, Atsushi, Murakami, Chikana, Anzai, Yojiro, Kato, Fumio
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154/1435/2417 631/326/22/1290 Anti-Bacterial Agents - pharmacology Azo Compounds - isolation & purification Azo Compounds - pharmacology Bacteriology Biomedical and Life Sciences Bioorganic Chemistry Chromobacterium - drug effects Indoles - metabolism Life Sciences Liquid chromatography Medicinal Chemistry Microbial Sensitivity Tests Microbiology Molecular Structure Nuclear Magnetic Resonance, Biomolecular Organic Chemistry original-article Quorum Sensing - drug effects Silica Streptomyces - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Quorum sensing is an important microbial signaling system that controls the expression of many virulence genes. Maniwamycins C–F, new compounds and quorum-sensing inhibitors, were isolated from the culture broth of Streptomyces sp. TOHO-M025 using a silica gel column and preparative HPLC. The structures of maniwamycins were elucidated by spectroscopic analyses, including NMR. The compounds each have an azoxy moiety. All maniwamycins inhibited violacein synthesis, which is controlled by quorum sensing, in Chromobacterium violaceum CV026.
ISSN:	0021-8820 1881-1469
DOI:	10.1038/ja.2015.126