The relationship between beta-catenin and apoptosis: A cytological and immunocytochemical examination

Highlights • The relationship between the activity of the Wnt/β-catenin signaling pathway and apoptosis has not been fully elucidated. • Immunocytochemical expression of β-catenin, active caspase 3, 8, and 9 were investigated in cervicovaginal smears. • The activity of the Wnt/β-catenin signaling pa...

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Veröffentlicht in:Tissue & cell 2016-06, Vol.48 (3), p.160-167
Hauptverfasser: Donmez, Hanife Guler, Demirezen, Sayeste, Beksac, Mehmet Sinan
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creator Donmez, Hanife Guler
Demirezen, Sayeste
Beksac, Mehmet Sinan
description Highlights • The relationship between the activity of the Wnt/β-catenin signaling pathway and apoptosis has not been fully elucidated. • Immunocytochemical expression of β-catenin, active caspase 3, 8, and 9 were investigated in cervicovaginal smears. • The activity of the Wnt/β-catenin signaling pathway was highly related to death-receptor mediated apoptosis. • The activity of the Wnt/β-catenin signaling pathway in non-apoptotic cells may be associated with the tissue homeostasis.
doi_str_mv 10.1016/j.tice.2016.04.001
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subjects Advanced Basic Science
Apoptosis
Apoptosis - genetics
beta Catenin - biosynthesis
beta Catenin - genetics
Beta-catenin
Caspase 3
Caspase 3 - metabolism
Caspase 8
Caspase 9
Epithelial Cells - metabolism
Female
Gene Expression Regulation
Humans
Receptors, Death Domain - biosynthesis
Receptors, Death Domain - isolation & purification
Vaginal Smears - methods
Wnt Signaling Pathway
Wnt/beta-catenin signaling pathway
title The relationship between beta-catenin and apoptosis: A cytological and immunocytochemical examination
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