Tissue-infiltrating plasma cells are an important source of carboxylesterase 2 contributing to the therapeutic efficacy of prodrugs

Highlights • CES-2 protein levels in colorectal cancer in situ are not related to tumor grade. • Independent of their origin neuroendocrine tumors are devoid of CES-2 protein. • CES-2high plasma cells are found in intestinal tissue of cancer and inflammation. • In hepatocytes, CES-2 expression decli...

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Veröffentlicht in:	Cancer letters 2016-08, Vol.378 (1), p.51-58
Hauptverfasser:	Kühl, Anja A, Erben, Ulrike, Cieluch, Constanze, Spieckermann, Simone, Gröne, Jörn, Lohneis, Philipp, Pape, Ulrich Frank, Arsenic, Ruza, Utku, Nalân
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation, Metabolic Adult Aged Aged, 80 and over Antineoplastic Agents - metabolism Antineoplastic Agents - therapeutic use Carboxylesterase - blood Carboxylesterase - genetics Carboxylesterase - metabolism Cloning Colon Colon - enzymology Colon - pathology Colorectal cancer Colorectal Neoplasms - drug therapy Colorectal Neoplasms - enzymology Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Enterohepatic Circulation Enzymes Female Gastrointestinal Agents - metabolism Gastrointestinal Agents - pharmacology Gene Expression Regulation, Enzymologic Glycerol HEK293 Cells Hematology, Oncology and Palliative Medicine Hepatocytes - enzymology HT29 Cells Humans Immunoglobulins Immunohistochemistry Inflammatory bowel disease Inflammatory Bowel Diseases - drug therapy Inflammatory Bowel Diseases - enzymology Inflammatory Bowel Diseases - genetics Inflammatory Bowel Diseases - pathology Jurkat Cells K562 Cells Leukocytes, Mononuclear - enzymology Male Middle Aged Neoplasm Grading Plasma Plasma cells Plasma Cells - enzymology Prodrugs - metabolism Prodrugs - therapeutic use Proteins Studies Tumors U937 Cells Young Adult
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Beschreibung
Zusammenfassung:	Highlights • CES-2 protein levels in colorectal cancer in situ are not related to tumor grade. • Independent of their origin neuroendocrine tumors are devoid of CES-2 protein. • CES-2high plasma cells are found in intestinal tissue of cancer and inflammation. • In hepatocytes, CES-2 expression declines during tumorigenesis. • Peripheral blood mononuclear cells of healthy donors express low levels of CES-2.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2016.04.041