CCR4 is critically involved in effective antitumor immunity in mice bearing intradermal b16 melanoma
Highlights • CCR4-deficient mice displayed enhanced tumor growth upon the inoculation of B16-F10. • CCR4-deficient mice have reduced tumor-infiltrating CD8+ effector T cells. • CCR4-deficient mice have reduced DC-Th17 cell clusters and Th17 cell expansion. • Administration of a CCR4 antagonist enhan...
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| Veröffentlicht in: | Cancer letters 2016-08, Vol.378 (1), p.16-22 |
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| container_title | Cancer letters |
| container_volume | 378 |
| creator | Matsuo, Kazuhiko Itoh, Tatsuki Koyama, Atsushi Imamura, Reira Kawai, Shiori Nishiwaki, Keiji Oiso, Naoki Kawada, Akira Yoshie, Osamu Nakayama, Takashi |
| description | Highlights • CCR4-deficient mice displayed enhanced tumor growth upon the inoculation of B16-F10. • CCR4-deficient mice have reduced tumor-infiltrating CD8+ effector T cells. • CCR4-deficient mice have reduced DC-Th17 cell clusters and Th17 cell expansion. • Administration of a CCR4 antagonist enhanced tumor growth and decreased Th17 cells. • The deficiency of CCR6 did not affect tumor growth and the number of Th17 cells. |
| doi_str_mv | 10.1016/j.canlet.2016.04.039 |
| format | Article |
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pharmacology</subject><subject>Cancer</subject><subject>CCR4</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation</subject><subject>Chemokine</subject><subject>Chemokine CCL22 - metabolism</subject><subject>Chemokines</subject><subject>Cloning</subject><subject>Colleges & universities</subject><subject>Dacarbazine - pharmacology</subject><subject>Dendritic Cells - immunology</subject><subject>Dendritic Cells - metabolism</subject><subject>Experiments</subject><subject>Genotype</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Immunology</subject><subject>Immunotherapy</subject><subject>Lymph Nodes - immunology</subject><subject>Lymph Nodes - metabolism</subject><subject>Lymphatic system</subject><subject>Lymphocytes</subject><subject>Lymphocytes, Tumor-Infiltrating - drug effects</subject><subject>Lymphocytes, Tumor-Infiltrating - immunology</subject><subject>Lymphocytes, Tumor-Infiltrating - metabolism</subject><subject>Medical prognosis</subject><subject>Melanoma</subject><subject>Melanoma, Experimental - drug therapy</subject><subject>Melanoma, Experimental - genetics</subject><subject>Melanoma, Experimental - immunology</subject><subject>Melanoma, Experimental - metabolism</subject><subject>Melanoma, Experimental - pathology</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><subject>Patients</subject><subject>Phenotype</subject><subject>Receptors, CCR4 - deficiency</subject><subject>Receptors, CCR4 - genetics</subject><subject>Receptors, CCR4 - immunology</subject><subject>Signal Transduction</subject><subject>T cell receptors</subject><subject>Th17</subject><subject>Th17 Cells - drug effects</subject><subject>Th17 Cells - immunology</subject><subject>Th17 Cells - metabolism</subject><subject>Time Factors</subject><subject>Transfection</subject><subject>Treg</subject><subject>Tumor Burden</subject><subject>Tumors</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkl2r1DAQhoMonvXoPxAJeONN66RJk-2NIItfcEDw4zqk04lkbdpj0i7svzdljwrnxqtk4Jk3k_cdxp4LqAUI_fpYo5tGWuqmVDWoGmT3gO3E3jSV6fbwkO1AgqrkXrZX7EnORwBolWkfs6vGCNl0-27HhsPhi-Ihc0xhCejG8czDdJrHEw3lwsl7wiWciLtpCcsa58RDjOsUlg3kMSDxnlwK049SL8kNlKIbeS80jzS6aY7uKXvk3Zjp2d15zb6_f_ft8LG6-fzh0-HtTYWtEEulutYP0mhnhEFNUqHu0TVa4l73Er03MODQ9k75HkzvBDXOo3Kqxw6lb-U1e3XRvU3zr5XyYmPISGOZguY1W2G6RhrQnSzoy3vocV7TVKbbKAHSCKULpS4UpjnnRN7ephBdOlsBdkvBHu0lBbulYEHZkkJpe3EnvvaRhr9Nf2wvwJsLQMWNU6BkMwaakIaQit12mMP_XrgvgGOYtvx-0pnyv7_Y3FiwX7dN2BZBaAmNaUH-Bu-isBw</recordid><startdate>20160801</startdate><enddate>20160801</enddate><creator>Matsuo, Kazuhiko</creator><creator>Itoh, Tatsuki</creator><creator>Koyama, Atsushi</creator><creator>Imamura, Reira</creator><creator>Kawai, Shiori</creator><creator>Nishiwaki, Keiji</creator><creator>Oiso, Naoki</creator><creator>Kawada, Akira</creator><creator>Yoshie, Osamu</creator><creator>Nakayama, Takashi</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20160801</creationdate><title>CCR4 is critically involved in effective antitumor immunity in mice bearing intradermal b16 melanoma</title><author>Matsuo, Kazuhiko ; Itoh, Tatsuki ; Koyama, Atsushi ; Imamura, Reira ; Kawai, Shiori ; Nishiwaki, Keiji ; Oiso, Naoki ; Kawada, Akira ; Yoshie, Osamu ; Nakayama, Takashi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c511t-495fd376a717c6e34c6bca263c86b3cff70dcd5ba4fb07ba1e2afc4a4bc9c3f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Antineoplastic Agents, Alkylating - 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genetics</topic><topic>Melanoma, Experimental - immunology</topic><topic>Melanoma, Experimental - metabolism</topic><topic>Melanoma, Experimental - pathology</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Knockout</topic><topic>Patients</topic><topic>Phenotype</topic><topic>Receptors, CCR4 - deficiency</topic><topic>Receptors, CCR4 - genetics</topic><topic>Receptors, CCR4 - immunology</topic><topic>Signal Transduction</topic><topic>T cell receptors</topic><topic>Th17</topic><topic>Th17 Cells - drug effects</topic><topic>Th17 Cells - immunology</topic><topic>Th17 Cells - metabolism</topic><topic>Time Factors</topic><topic>Transfection</topic><topic>Treg</topic><topic>Tumor Burden</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Matsuo, Kazuhiko</creatorcontrib><creatorcontrib>Itoh, Tatsuki</creatorcontrib><creatorcontrib>Koyama, Atsushi</creatorcontrib><creatorcontrib>Imamura, Reira</creatorcontrib><creatorcontrib>Kawai, Shiori</creatorcontrib><creatorcontrib>Nishiwaki, Keiji</creatorcontrib><creatorcontrib>Oiso, Naoki</creatorcontrib><creatorcontrib>Kawada, Akira</creatorcontrib><creatorcontrib>Yoshie, Osamu</creatorcontrib><creatorcontrib>Nakayama, Takashi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - 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| identifier | ISSN: 0304-3835 |
| ispartof | Cancer letters, 2016-08, Vol.378 (1), p.16-22 |
| issn | 0304-3835 1872-7980 |
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| subjects | Animals Antineoplastic Agents, Alkylating - pharmacology Cancer CCR4 Cell Line, Tumor Cell Proliferation Chemokine Chemokine CCL22 - metabolism Chemokines Cloning Colleges & universities Dacarbazine - pharmacology Dendritic Cells - immunology Dendritic Cells - metabolism Experiments Genotype Hematology, Oncology and Palliative Medicine Immunology Immunotherapy Lymph Nodes - immunology Lymph Nodes - metabolism Lymphatic system Lymphocytes Lymphocytes, Tumor-Infiltrating - drug effects Lymphocytes, Tumor-Infiltrating - immunology Lymphocytes, Tumor-Infiltrating - metabolism Medical prognosis Melanoma Melanoma, Experimental - drug therapy Melanoma, Experimental - genetics Melanoma, Experimental - immunology Melanoma, Experimental - metabolism Melanoma, Experimental - pathology Mice, Inbred C57BL Mice, Knockout Patients Phenotype Receptors, CCR4 - deficiency Receptors, CCR4 - genetics Receptors, CCR4 - immunology Signal Transduction T cell receptors Th17 Th17 Cells - drug effects Th17 Cells - immunology Th17 Cells - metabolism Time Factors Transfection Treg Tumor Burden Tumors |
| title | CCR4 is critically involved in effective antitumor immunity in mice bearing intradermal b16 melanoma |
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