CCR4 is critically involved in effective antitumor immunity in mice bearing intradermal b16 melanoma

Highlights • CCR4-deficient mice displayed enhanced tumor growth upon the inoculation of B16-F10. • CCR4-deficient mice have reduced tumor-infiltrating CD8+ effector T cells. • CCR4-deficient mice have reduced DC-Th17 cell clusters and Th17 cell expansion. • Administration of a CCR4 antagonist enhan...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer letters 2016-08, Vol.378 (1), p.16-22
Hauptverfasser:	Matsuo, Kazuhiko, Itoh, Tatsuki, Koyama, Atsushi, Imamura, Reira, Kawai, Shiori, Nishiwaki, Keiji, Oiso, Naoki, Kawada, Akira, Yoshie, Osamu, Nakayama, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents, Alkylating - pharmacology Cancer CCR4 Cell Line, Tumor Cell Proliferation Chemokine Chemokine CCL22 - metabolism Chemokines Cloning Colleges & universities Dacarbazine - pharmacology Dendritic Cells - immunology Dendritic Cells - metabolism Experiments Genotype Hematology, Oncology and Palliative Medicine Immunology Immunotherapy Lymph Nodes - immunology Lymph Nodes - metabolism Lymphatic system Lymphocytes Lymphocytes, Tumor-Infiltrating - drug effects Lymphocytes, Tumor-Infiltrating - immunology Lymphocytes, Tumor-Infiltrating - metabolism Medical prognosis Melanoma Melanoma, Experimental - drug therapy Melanoma, Experimental - genetics Melanoma, Experimental - immunology Melanoma, Experimental - metabolism Melanoma, Experimental - pathology Mice, Inbred C57BL Mice, Knockout Patients Phenotype Receptors, CCR4 - deficiency Receptors, CCR4 - genetics Receptors, CCR4 - immunology Signal Transduction T cell receptors Th17 Th17 Cells - drug effects Th17 Cells - immunology Th17 Cells - metabolism Time Factors Transfection Treg Tumor Burden Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • CCR4-deficient mice displayed enhanced tumor growth upon the inoculation of B16-F10. • CCR4-deficient mice have reduced tumor-infiltrating CD8+ effector T cells. • CCR4-deficient mice have reduced DC-Th17 cell clusters and Th17 cell expansion. • Administration of a CCR4 antagonist enhanced tumor growth and decreased Th17 cells. • The deficiency of CCR6 did not affect tumor growth and the number of Th17 cells.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2016.04.039