Protein Binding and Metabolism Influence the Relative Skin Sensitization Potential of Cinnamic Compounds

Skin protein modification (haptenation) is thought to be a key step in the manifestation of sensitization to low molecular mass chemicals (

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical research in toxicology 2004-03, Vol.17 (3), p.301-310
Hauptverfasser:	Elahi, Eiram N, Wright, Zoe, Hinselwood, David, Hotchkiss, Sharon A. M, Basketter, David A, Smith Pease, Camilla K
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrolein - analogs & derivatives Acrolein - pharmacokinetics Acrolein - toxicity Aldehydes - pharmacokinetics Aldehydes - toxicity Animals Dermatitis, Contact - etiology Dermatitis, Contact - metabolism Dermatitis, Contact - pathology Dose-Response Relationship, Drug Female Humans Immunoenzyme Techniques Local Lymph Node Assay Propanols - pharmacokinetics Propanols - toxicity Protein Binding Rabbits Rats Rats, Inbred F344 Skin - drug effects Skin - metabolism Skin - pathology
Online-Zugang:	Volltext
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