Protein Binding and Metabolism Influence the Relative Skin Sensitization Potential of Cinnamic Compounds

Protein Binding and Metabolism Influence the Relative Skin Sensitization Potential of Cinnamic Compounds

Skin protein modification (haptenation) is thought to be a key step in the manifestation of sensitization to low molecular mass chemicals (

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Bibliographische Detailangaben
Veröffentlicht in:Chemical research in toxicology 2004-03, Vol.17 (3), p.301-310
Hauptverfasser: Elahi, Eiram N, Wright, Zoe, Hinselwood, David, Hotchkiss, Sharon A. M, Basketter, David A, Smith Pease, Camilla K
Format: Artikel
Sprache:eng
Schlagworte:
Acrolein - analogs & derivatives
Acrolein - pharmacokinetics
Acrolein - toxicity
Aldehydes - pharmacokinetics
Aldehydes - toxicity
Animals
Dermatitis, Contact - etiology
Dermatitis, Contact - metabolism
Dermatitis, Contact - pathology
Dose-Response Relationship, Drug
Female
Humans
Immunoenzyme Techniques
Local Lymph Node Assay
Propanols - pharmacokinetics
Propanols - toxicity
Protein Binding
Rabbits
Rats
Rats, Inbred F344
Skin - drug effects
Skin - metabolism
Skin - pathology
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Beschreibung
Zusammenfassung:Skin protein modification (haptenation) is thought to be a key step in the manifestation of sensitization to low molecular mass chemicals (
ISSN:0893-228X
1520-5010
DOI:10.1021/tx0341456