Serum ST2 in inflammatory bowel disease: a potential biomarker for disease activity

ST2, a specific ligand of interleukin 33, was described as a biomarker protein of inflammatory processes and overexpression of ST2 in ulcerative colitis (UC) was shown previously. We aimed to investigate the potential relationship of serum ST2 levels with the clinical, endoscopic and histopathologic...

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Veröffentlicht in:	Journal of investigative medicine 2016-06, Vol.64 (5), p.1016-1024
Hauptverfasser:	Boga, Salih, Alkim, Huseyin, Koksal, Ali Riza, Ozagari, Ayse Aysim, Bayram, Mehmet, Tekin Neijmann, Sebnem, Sen, Ilker, Alkim, Canan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biomarkers - blood Case-Control Studies Colitis, Ulcerative - blood Crohn Disease - blood Endoscopy Female Humans Inflammatory bowel disease Inflammatory Bowel Diseases - blood Interleukin-1 Receptor-Like 1 Protein - blood Male ROC Curve Severity of Illness Index
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Zusammenfassung:	ST2, a specific ligand of interleukin 33, was described as a biomarker protein of inflammatory processes and overexpression of ST2 in ulcerative colitis (UC) was shown previously. We aimed to investigate the potential relationship of serum ST2 levels with the clinical, endoscopic and histopathological activity scores in UC and Crohn's disease (CD). Serum ST2 levels were determined in 143 patients with inflammatory bowel disease (IBD) (83 UC and 60 CD), in 50 healthy controls (HC), and in 32 patients with irritable bowel syndrome (IBS). Serum ST2 levels were elevated in IBD (56.8 (41.9–87.2) pg/mL) compared to HC and IBS (30.7 (20.2–54.3), p
ISSN:	1081-5589 1708-8267
DOI:	10.1136/jim-2016-000062