Painful small fiber neuropathy with gastroparesis: A new phenotype with a novel mutation in the SCN10A gene

Highlights • Mutations in the Nav 1.8 sodium channel may cause painful sensory neuropathy. • Gastroparesis may be a part of the clinical spectrum of Nav 1.8 mutations. • Painful neuropathy with GI motility dysfunction may suggest Nav 1.8 channelopathy.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of clinical neuroscience 2016-04, Vol.26, p.84-88
Hauptverfasser:	Dabby, Ron, Sadeh, Menachem, Broitman, Yelena, Yosovich, Keren, Dickman, Ram, Leshinsky-Silver, Esther
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Autonomic neuropathy Erythromelalgia - complications Erythromelalgia - genetics Female Ganglia, Spinal Gastroparesis Gastroparesis - complications Gastroparesis - genetics Humans Mutation Nav1.8 sodium channel NAV1.8 Voltage-Gated Sodium Channel - genetics Neurology Neuropathic pain Nociceptors Pain - complications Pain - genetics Peripheral Nervous System Diseases - complications Peripheral Nervous System Diseases - genetics Phenotype SCN10A Small fiber neuropathy
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Beschreibung
Zusammenfassung:	Highlights • Mutations in the Nav 1.8 sodium channel may cause painful sensory neuropathy. • Gastroparesis may be a part of the clinical spectrum of Nav 1.8 mutations. • Painful neuropathy with GI motility dysfunction may suggest Nav 1.8 channelopathy.
ISSN:	0967-5868 1532-2653
DOI:	10.1016/j.jocn.2015.05.071