Increased expression of Toll-like receptors 7 and 9 in myasthenia gravis thymus characterized by active Epstein–Barr virus infection

Highlights • TLR7 and TLR9 mRNA levels are increased in EBV-infected MG thymuses. • TLR7 and TLR9 are overexpressed in MG thymic B cells and co-localize with EBV. • MG thymuses show an increased proportion of proliferating B cells. • TLR7 and TLR9 are overexpressed in MG thymic epithelium, pDCs and...

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Veröffentlicht in:	Immunobiology (1979) 2016-04, Vol.221 (4), p.516-527
Hauptverfasser:	Cavalcante, Paola, Galbardi, Barbara, Franzi, Sara, Marcuzzo, Stefania, Barzago, Claudia, Bonanno, Silvia, Camera, Giorgia, Maggi, Lorenzo, Kapetis, Dimos, Andreetta, Francesca, Biasiucci, Amelia, Motta, Teresio, Giardina, Carmelo, Antozzi, Carlo, Baggi, Fulvio, Mantegazza, Renato, Bernasconi, Pia
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Advanced Basic Science Allergy and Immunology Antigens, Viral - genetics Antigens, Viral - immunology B-Lymphocytes - immunology B-Lymphocytes - pathology B-Lymphocytes - virology Cell Proliferation Dendritic Cells - immunology Dendritic Cells - pathology Dendritic Cells - virology Epstein-Barr virus Epstein-Barr Virus Infections - complications Epstein-Barr Virus Infections - immunology Epstein-Barr Virus Infections - pathology Epstein-Barr Virus Infections - virology Female Gene Expression Regulation Germinal Center - immunology Germinal Center - pathology Germinal Center - virology Herpesvirus 4, Human Humans Interferon-beta - genetics Interferon-beta - immunology Ki-67 Antigen - genetics Ki-67 Antigen - immunology Lymphocyte Activation Macrophages - immunology Macrophages - pathology Macrophages - virology Male Myasthenia gravis Myasthenia Gravis - complications Myasthenia Gravis - immunology Myasthenia Gravis - pathology Myasthenia Gravis - virology RNA, Messenger - genetics RNA, Messenger - immunology Signal Transduction Thymus Thymus Gland - immunology Thymus Gland - pathology Thymus Gland - virology Toll-like receptor 7 Toll-Like Receptor 7 - genetics Toll-Like Receptor 7 - immunology Toll-like receptor 9 Toll-Like Receptor 9 - genetics Toll-Like Receptor 9 - immunology
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Zusammenfassung:	Highlights • TLR7 and TLR9 mRNA levels are increased in EBV-infected MG thymuses. • TLR7 and TLR9 are overexpressed in MG thymic B cells and co-localize with EBV. • MG thymuses show an increased proportion of proliferating B cells. • TLR7 and TLR9 are overexpressed in MG thymic epithelium, pDCs and macrophages. • In EBV-positive MG thymuses, TLR7 mRNA levels correlate with those of INF-β.
ISSN:	0171-2985 1878-3279
DOI:	10.1016/j.imbio.2015.12.007