TERT mutation in glioma: Frequency, prognosis and risk

Highlights • TERT mutations occurred frequently in GBM and oligodendrogliomas. • TERT promoter 292 mutations confer a poor prognosis on glioma patients. • TERT polymorphisms were associated with an increased risk of glioma.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of clinical neuroscience 2016-04, Vol.26, p.57-62
Hauptverfasser:	Yuan, Yang, Qi, Chen, Maling, Gou, Xiang, Wang, Yanhui, Liu, Ruofei, Liang, Yunhe, Mao, Jiewen, Luo, Qing, Mao
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain Neoplasms - genetics Brain Neoplasms - pathology Frequency Genetic Predisposition to Disease Glioma Glioma - genetics Glioma - pathology Humans Mutation Neurology Polymorphism, Genetic Prognosis Promoter Regions, Genetic Risk Survival Telomerase - genetics TERT
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Beschreibung
Zusammenfassung:	Highlights • TERT mutations occurred frequently in GBM and oligodendrogliomas. • TERT promoter 292 mutations confer a poor prognosis on glioma patients. • TERT polymorphisms were associated with an increased risk of glioma.
ISSN:	0967-5868 1532-2653
DOI:	10.1016/j.jocn.2015.05.066