Phase shifts to light are altered by antagonists to neuropeptide receptors

Highlights • Gastrin-releasing peptide antagonists do not block circadian responses to light. • Vasoactive intestinal peptide antagonists do not block photic phase shifts. • A cocktail of specific GRP and VIP antagonists attenuate photic phase shifts. • The GRP antagonist RC3095 potentiates photic p...

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Veröffentlicht in:	Neuroscience 2016-07, Vol.327, p.115-124
Hauptverfasser:	Chan, Ryan K, Sterniczuk, Roxanne, Enkhbold, Yaruuna, Jeffers, Ryan T, Basu, Priyoneel, Duong, Bryan, Chow, Sue-Len, Smith, Victoria M, Antle, Michael C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals bombesin Bombesin - analogs & derivatives Bombesin - pharmacology Circadian Rhythm - physiology core Cricetinae Gastrin-Releasing Peptide - metabolism Light Male network Neurology Peptide Fragments - pharmacology Photic Stimulation - methods Receptors, Neuropeptide - antagonists & inhibitors Receptors, Neuropeptide - metabolism rodent shell Suprachiasmatic Nucleus - drug effects Suprachiasmatic Nucleus - physiology Vasoactive Intestinal Peptide - metabolism
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Zusammenfassung:	Highlights • Gastrin-releasing peptide antagonists do not block circadian responses to light. • Vasoactive intestinal peptide antagonists do not block photic phase shifts. • A cocktail of specific GRP and VIP antagonists attenuate photic phase shifts. • The GRP antagonist RC3095 potentiates photic phase shifts.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2016.04.010