Gene-environment interactions in obesity: implication for future applications in preventive medicine

Obesity is associated with environmental factors; however, information about gene-environment interactions is lacking. We aimed to elucidate the effects of gene-environment interactions on obesity, specifically between genetic predisposition and various obesity-related lifestyle factors, using data...

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Veröffentlicht in:	Journal of human genetics 2016-04, Vol.61 (4), p.317-322
Hauptverfasser:	Nakamura, Sho, Narimatsu, Hiroto, Sato, Hidenori, Sho, Ri, Otani, Katsumi, Kawasaki, Ryo, Karasawa, Shigeru, Daimon, Makoto, Yamashita, Hidetoshi, Kubota, Isao, Ueno, Yoshiyuki, Kato, Takeo, Yoshioka, Takashi, Fukao, Akira, Kayama, Takamasa
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Body Mass Index Gene-Environment Interaction Genetic Predisposition to Disease Genotype Humans Middle Aged Obesity - genetics Obesity - pathology Polymorphism, Single Nucleotide Risk Factors
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Beschreibung
Zusammenfassung:	Obesity is associated with environmental factors; however, information about gene-environment interactions is lacking. We aimed to elucidate the effects of gene-environment interactions on obesity, specifically between genetic predisposition and various obesity-related lifestyle factors, using data from a population-based prospective cohort study. The genetic risk score (GRS) calculated from East Asian ancestry single-nucleotide polymorphisms was significantly associated with the body mass index (BMI) at baseline (P
ISSN:	1434-5161 1435-232X
DOI:	10.1038/jhg.2015.148