Novel markers of inflammatory response and hepatic dysfunction in canine leishmaniasis

Highlights • Visceral leishmaniasis is an immunomediated disease and dogs are the main host. • ADA and BChE are key enzymes in many physiological processes, including inflammation. • There are reports of failure on cellular response in symptomatic dogs. • ADA, BChE activities were accessed in dogs n...

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Veröffentlicht in:	Comparative immunology, microbiology and infectious diseases microbiology and infectious diseases, 2016-02, Vol.44, p.61-64
Hauptverfasser:	Tonin, Alexandre A, Calado, Andréa M.C, Bottari, Nathieli B, Dalenogare, Diéssica, Thomé, Gustavo R, Duarte, Thiago, Duarte, Marta M.M.F, Morsch, Vera M, Schetinger, Maria R.C, Alves, Leucio C, Tinucci-Costa, Mirela, Da Silva, Aleksandro S
Format:	Artikel
Sprache:	eng
Schlagworte:	ADA Adenosine Deaminase - blood Allergy and Immunology Animals BChE Biomarkers - blood Butyrylcholinesterase - blood Cytokines Cytokines - blood Dog Diseases - diagnosis Dog Diseases - immunology Dog Diseases - parasitology Dog Diseases - physiopathology Dogs Down-Regulation Infectious Disease Inflammation - parasitology Inflammation - veterinary Interferon-gamma - immunology Leishmania Leishmania infantum Leishmaniasis, Visceral - immunology Leishmaniasis, Visceral - parasitology Leishmaniasis, Visceral - physiopathology Leishmaniasis, Visceral - veterinary Liver - metabolism Liver - parasitology Liver - physiopathology
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Beschreibung
Zusammenfassung:	Highlights • Visceral leishmaniasis is an immunomediated disease and dogs are the main host. • ADA and BChE are key enzymes in many physiological processes, including inflammation. • There are reports of failure on cellular response in symptomatic dogs. • ADA, BChE activities were accessed in dogs naturally infected by Leishmania donovani. • ADA and BChE activities reduced in sera of naturally infected dogs.
ISSN:	0147-9571 1878-1667
DOI:	10.1016/j.cimid.2015.09.004