Lanostane-type triterpenes from the fungal endophyte Scleroderma UFSMSc1 (Persoon) Fries

Sclerodols A and B, two anticandidal lanostane triterpenoids, were isolated from the culture of the Eucalyptus grandis-derived from the fungal endophyte Scleroderma UFSMSc1 (Persoon) Fries, together with the known triterpenoid lanosta-8,23-dien-3β,25-diol. [Display omitted] Two lanostane triterpenoids (sclerodols A and B) were isolated from the culture of the Eucalyptus grandis derived from the endophyte Scleroderma UFSM Sc1(Persoon) Fries together with three known compounds: one related triterpenoid lanosta-8,23-dien-3β,25-diol, the disaccharide α,β-trehalose, and the sugar alcohol mannitol. Their structures were elucidated on the basis of 2D NMR, HRME, and single-crystal X-ray diffraction data. The methanol crude extract and the isolated lanostane triterpenoids showed promising anticandidal activities.