Antigenotoxic potential of curcumin and carvacrol against malathion-induced DNA damage in cultured human peripheral blood and its relation to GSTM1 and GSTT1 polymorphism

Antigenotoxic potential of curcumin and carvacrol against malathion-induced DNA damage in cultured human peripheral blood and its relation to GSTM1 and GSTT1 polymorphism

Abstract The aerial application of malathion, a widely used organophosphate insecticide, has raised public concerns about its potential adverse health effects. We, therefore, studied the antigenotoxic potential of curcumin and carvacrol against malathion-induced DNA damage using sister chromatid exc...

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Veröffentlicht in:Biomarkers and genomic medicine 2015-09, Vol.7 (3), p.98-104
Hauptverfasser: Kumar, Neeraj, Yadav, Anita, Gulati, Sachin, Kanupriya, Aggarwal, Neeraj, Gupta, Ranjan
Format: Artikel
Sprache:eng
Schlagworte:
Advanced Basic Science
carvacrol
curcumin
genetic polymorphism
malathion
Medical Education
sister chromatid exchange
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Zusammenfassung:Abstract The aerial application of malathion, a widely used organophosphate insecticide, has raised public concerns about its potential adverse health effects. We, therefore, studied the antigenotoxic potential of curcumin and carvacrol against malathion-induced DNA damage using sister chromatid exchange (SCE) as a biomarker of genotoxicity. To observe the antigenotoxic potential of curcumin and carvacrol, heparinized fresh blood from healthy individuals was treated with 30 μg/mL of malathion in the presence of curcumin and carvacrol. Curcumin at concentrations of 25 μg/mL and 50 μg/mL had significantly reduced ( p  
ISSN:2214-0247
2214-0255
DOI:10.1016/j.bgm.2015.02.002