Orexin and sleep quality in anorexia nervosa: Clinical relevance and influence on treatment outcome

Highlights • The link between orexin-A and sleep in anorexia nervosa has not been explored. • Anorexia nervosa patients reported overall poorer sleep versus healthy controls. • No differences were found between the patients and healthy controls in orexin-A. • Orexin-A concentrations and poorer sleep were related. • High orexin-A levels and inefficient sleep contributed to poor treatment outcome.