The prevalence and predictors of bipolar and borderline personality disorders comorbidity: Systematic review and meta-analysis

Abstract Introduction Data about the prevalence of borderline personality (BPD) and bipolar (BD) disorders comorbidity are scarce and the boundaries remain controversial. We conducted a systematic review and meta-analysis investigating the prevalence of BPD in BD and BD in people with BPD. Methods Two independent authors searched MEDLINE, Embase, PsycINFO and the Cochrane Library from inception till November 4, 2015. Articles reporting the prevalence of BPD and BD were included. A random effects meta-analysis and meta-regression were conducted. Results Overall, 42 papers were included: 28 considering BPD in BD and 14 considering BD in BPD. The trim and fill adjusted analysis demonstrated the prevalence of BPD among 5273 people with BD (39.94±11.78 years, 44% males) was 21.6% (95% CI 17.0–27.1). Higher comorbid BPD in BD were noted in BD II participants (37.7%, 95% CI 21.9–56.6, studies=6) and North American studies (26.2%, 95% CI 18.7–35.3, studies=11). Meta regression established that a higher percentage of males and higher mean age significantly (p