The RNA binding proteins RBM38 and DND1 are repressed in AML and have a novel function in APL differentiation
Highlights • RBM38 and DND1 expression is attenuated in primary AML patients. • Normal and leukemic neutrophil differentiation induces RBM38 and DND1 expression. • New function for the RNA binding proteins RBM38 and DND1 in APL differentiation.
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| Veröffentlicht in: | Leukemia research 2016-02, Vol.41, p.96-102 |
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| container_end_page | 102 |
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| container_issue | |
| container_start_page | 96 |
| container_title | Leukemia research |
| container_volume | 41 |
| creator | Wampfler, Julian Federzoni, Elena A Torbett, Bruce E Fey, Martin F Tschan, Mario P |
| description | Highlights • RBM38 and DND1 expression is attenuated in primary AML patients. • Normal and leukemic neutrophil differentiation induces RBM38 and DND1 expression. • New function for the RNA binding proteins RBM38 and DND1 in APL differentiation. |
| doi_str_mv | 10.1016/j.leukres.2015.12.006 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0145-2126 |
| ispartof | Leukemia research, 2016-02, Vol.41, p.96-102 |
| issn | 0145-2126 1873-5835 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Acute myeloid leukemia Acute promyelocytic leukemia Adolescent Adult Aged Blotting, Western Cell Differentiation DND1 Female Gene Expression Regulation, Leukemic - physiology Gene Knockdown Techniques Hematology, Oncology and Palliative Medicine Humans Leukemia, Myeloid, Acute - pathology Leukemia, Promyelocytic, Acute - pathology Male Middle Aged Neoplasm Proteins - biosynthesis Neutrophil differentiation Neutrophils - pathology RBM38 Real-Time Polymerase Chain Reaction RNA-Binding Proteins - biosynthesis Young Adult |
| title | The RNA binding proteins RBM38 and DND1 are repressed in AML and have a novel function in APL differentiation |
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